Few See Renewed Role for Rosiglitazone in Diabetes
Lisa Nainggolan
Following the US Food and Drug Administration (FDA) decision yesterday to lift the restrictions on the type 2 diabetes drug rosiglitazone (Avandia, GlaxoSmithKline) and any rosiglitazone-containing products or generics, the big question now is whether the product will ever be "resurrected."
Just one in three US patients has control of BP and cholesterol
Charleston, SC - Less than one in three patients in the US have their blood-pressure and cholesterol levels under control, according to a new analysis of the National Health and Nutrition Examination Surveys (NHANES) [1]. Researchers say there exist significant opportunities for reaching national coronary heart disease prevention goals by improving hypertension and cholesterol control.
Aggressive glucose control no benefit in CV surgery patients with T2D
Chicago, IL - An aggressive approach to glucose control for diabetic patients undergoing elective cardiac surgery does not improve outcomes or reduce length of stay—and may even be harmful, the Neurological Outcomes in Diabetics Undergoing Cardiovascular Surgery (NODS) trial suggests
Stress CT perfusion matches SPECT for detecting myocardial ischemia
Montreal, QC - In stress testing using regadenoson (Lexiscan, Astellas), detection rates of myocardial ischemia were similar with less invasive computed-tomography (CT) perfusion imaging compared with the reference method, single-photon-emission CT (SPECT) imaging, in a phase 2 trial.
Perioperative beta-blocker controversy begins again with new meta-analysis
London, UK - The debate over the perioperative use of beta-blockers in noncardiac surgery is flaring up once again with the publication of a new meta-analysis suggesting their use increases the risk of death [1]. In an analysis that excluded discredited clinical trials, investigators report that treatment of patients undergoing noncardiac surgery with beta-blockers resulted in a statistically significant 27% increased mortality risk.
ACE inhibitors may slow cognitive decline
Cork, Ireland and Hamilton, ON - Centrally acting ACE inhibitors reduce the rate of cognitive decline in patients with dementia, regardless of blood-pressure levels at the time of their hypertension diagnosis, a new study has found
Some antihypertensives linked to breast-cancer risk
Boston, MA - The first observational study of long-term antihypertensive use and breast-cancer risk found that calcium-channel blockers (CCBs) were associated with a more than twofold increased risk, while ACE inhibitors appeared to be associated with a reduced risk.
Early surgery bests "watchful waiting" in severe MR patients without symptoms
Rochester, MN - Patients with severe mitral regurgitation (MR) without a class I indication for surgical intervention fared significantly better when treated with surgery than patients who underwent "watchful waiting" while treated with medical therapy, according to the results of a new analysis, published in the August 14, 2013 issue of the Journal of the American Medical Association
Who, what, when? Questions over Heartware ENDURANCE trial
Framingham, MA - One of the principal investigators for the pivotal ENDURANCE trial testing HeartWare International’s ventricular-assist device (VAD) as destination therapy says he still plans to present the full results late next year.
Physician continuity important in reducing HF outcomes
Edmonton, AB - Patients hospitalized with heart failure have significantly better clinical outcomes if they are followed up with a physician early after hospital discharge, a new study shows [1]. Physician continuity, however—defined as seeing a doctor already familiar with the patient—was associated with significantly better outcomes than seeing an unfamiliar physician.
New AHA Statement on Ischemia After Cardiac Surgery
The American Heart Association (AHA) outlines "considerations" on the management of acute postoperative myocardial ischemia (PMI) after cardiac surgery in a scientific statement.
New ESH Hypertension Guidelines Aim for Simplified Message
The European Society of Hypertension (ESH) has released updated and expanded guidelines for the management of hypertension.
Mediterranean Diet With Olive Oil Boosted HDL Function?
More research suggests that a Mediterranean-style diet supplemented with either virgin olive oil or mixed nuts enhances the function of HDL cholesterol[1].
In a subset of 296 patients at high risk of heart disease in thePREDIMED study, cholesterol efflux capacity (CEC), the first step in reverse cholesterol transport, was significantly increased at 1 year compared with baseline in those advised to eat a Mediterranean diet rich in virgin olive oil (VOO) (P=0.018) or mixed nuts (P=0.013) rather than a reduced-fat diet.
International Heart and Vascular Disease Journal-Issues
International Heart and Vascular Disease Journal
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