Sleep Disorders Linked to Aortic Stenosis

Researchers analyzed data from the TriNetX network and the All of Us study to examine the association between sleep disorders and the future incidence of aortic stenosis. A test cohort used data from 8.8 million patients aged > 50 years with or without sleep disorders. A validation cohort used data from 392,259 participants in the United States, 70,070 of whom had been diagnosed with a sleep disorder Cox proportional hazards models were used to assess the risk for aortic stenosis in patients with sleep disorders, adjusting for hypertension, hyperlipidemia, diabetes, chronic kidney disease, sex at birth, and body mass index. The researchers analyzed biochemical data were to explore potential mechanisms, focusing on lipid profiles and the role of lipids in mediating the association between sleep disorders and aortic stenosis.

TAKEAWAY

• Data from the TriNetX database showed the presence of any sleep disorder was associated with an increased risk for aortic stenosis (hazard ratio [HR], 1.15; 95% CI, 1.13-1.83), with the strongest association observed for sleep apnea (HR, 1.2; 95% CI, 1.17-1.24).
• Similar results were observed for patients in the All of Us cohort, confirming the increased risk for aortic stenosis in those with any sleep disorder (HR, 1.4; 95% CI, 1.12-1.77).
• Although sleep disorders were linked to a smaller proportion of cases of aortic stenosis during the follow-up period (population attributable fraction [PAF], 4.35%) than major risk factors like obesity (PAF, 33.2%), their effect was similar to that of chronic kidney disease (PAF, 4.4%).

 

https://www.medscape.com/viewarticle/sleep-disorders-linked-aortic-stenosis-2025a10006fx