High Salivary Aldosterone Can Signal Future Heart Disease

This cross-sectional analysis included 60 patients with coronary heart disease (mean age, 65.93 years), 40 patients with essential hypertension (mean age, 51.80 years), and 44 control individuals with normotension (mean age, 51.57 years).

The salivary free AldAR was repeatedly evaluated on 2 consecutive days using saliva samples collected immediately after awakening and at 15, 30, 45, and 60 minutes thereafter.

The prospective analysis followed 97 participants for a mean duration of 2.95 years and assessed changes in biological risk factors such as inflammatory markers and blood lipid profiles.

TAKEAWAY:

  • Men with coronary heart disease showed the expected post-awakening AldAR (P = .024) but had lower overall aldosterone levels than those with normotension.
  • Compared with men with normotension, those with essential hypertension had higher overall aldosterone levels (P = .010) but a flattened AldAR (P = .89).
  • Higher AldAR area under the curve (AUCAldAR) independently predicted greater increases in inflammatory parameters (P = .024).
  • Higher AUCAldAR was associated with greater increases in low-density lipoprotein cholesterol (P = .037) and total cholesterol (P = .032) levels in a univariate analysis; however, these associations weakened to trend levels after further adjustment for covariates.

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