CARDIOPROGRESS
Foundation for the advancement of cardiology

Ventricular arrhythmias during exercise in patients with mitral valve prolapse Mitral valve prolapse may be associated with ventricular arrhythmias, but little is known about the relationship between VA and exercise in these patients.

Risk and protective factors for stroke and transient ischaemic attack in patients with atrial fibrillation: an umbrella review of meta-analyses Atrial fibrillation is linked to significant morbidity and mortality, with ischaemic stroke being a leading cause of death. Identifying modifiable risk and protective factors may help reduce stroke incidence in patients with atrial fibrillation.

Chewing sugary gum may enhance the cardiovascular benefits of nitrate-rich vegetables For the first time, researchers at King's College London have discovered a link between chewing sugary gum after consuming vegetables high in nitrate, such as beetroot, spinach and kale, and lowering blood pressure.

Epigenetic drugs could protect blood vessels in obesity and diabetes Scientists from Zurich, together with colleagues from Italy, have proved that by acting on epigenetic "switches", early damage to blood vessels can be reversed. People with obesity and type 2 diabetes are at increased risk of cardiovascular complications. However, the danger depends not only on heredity, but also on how genes work.

Non-atherosclerotic myocardial infarction in hypereosinophilic syndrome: emerging insights and therapeutic approaches Hypereosinophilic syndrome (HES) is a heterogeneous disorder characterised by persistent, abnormal eosinophil elevation in blood and tissues, with multisystem involvement. Cardiac manifestations are frequent in HES and significantly worsen prognosis. Recent evidence establishes a direct link between HES and myocardial infarction (MI), demonstrating that HES induces MI primarily via non-atherosclerotic mechanisms.

Accelerated biological ageing and cardiovascular disease trajectories: a multistate analysis Accelerated biological ageing has been linked to elevated risks of hypertension (HTN) and cardiovascular diseases (CVDs), yet its role in shaping the dynamic progression from health to HTN, to CVDs, and ultimately to mortality remains poorly understood. In this regard, the data of 136,614 participants of the UK Biobank aged 38 to 73 years, who did not have hypertension and CVD at the initial stage, were analyzed.

Diagnostic performance of exercise stress testing findings and coronary microvascular dysfunction in patients with angina with non-obstructive coronary artery disease Coronary microvascular dysfunction (CMD) is common among patients with angina with non-obstructive coronary artery disease (ANOCA) and leads to poorer clinical outcomes. Exercise stress testing (EST) was shown to have a high specificity for detecting CMD. However, the relationship between diagnosing CMD using different invasive physiological parameters and thresholds and the association between EST findings and the endotype of CMD remains unknown.

Engineered blood clots stop bleeding in seconds The blood in the vascular system of the body supports vital functions, but when it leaves the body, it must quickly form a strong protective barrier — a clot that prevents death. However, because natural blood clots are known to form very slowly, heavy bleeding from accidents, battlefield injuries, and surgical complications leads to many potentially preventable deaths. In an article for the journal Nature, Jiang et al. They talked about the achievements of bioengineering that solve this problem by fundamentally changing the structure of blood clots.

Cardiac resynchronisation therapy among adults with a systemic right ventricle: a multicentre experience Researchers conducted an international retrospective study including patients over 18 years of age from 33 centers with transposition of the great arteries (TGA) after atrial switch surgery and congenitally corrected TGA.

Cardiovascular disease in Sickle cell: mechanisms, diagnostics and therapeutic advances Cardiovascular complications are increasingly recognized as a major cause of morbidity and early mortality in patients with sickle cell disease, yet they remain underdiagnosed and underestimated. In a new review, the authors summarize current knowledge on a wide range of cardiovascular manifestations, including myocardial dysfunction, pulmonary hypertension, cardiac iron overload, arrhythmia, myocardial infarction, stroke, and sudden death, with an emphasis on their unique pathophysiological mechanisms in Wolf-Hirschhorn syndrome.

Obesity and CVD: Launching the Heart Foundation's new clinical consensus statement In Australia, about two-thirds of adults are overweight or obese, placing them at increased risk of cardiovascular disease (CVD) including coronary heart disease, heart failure, and arrhythmias. The Heart Foundation recently launched an Australian-first clinical consensus statement on obesity and CVD.

Simulation deficit in cardiology training: a missed opportunity for the modern trainee Cardiology training today exists in a paradox. As the specialty becomes more complex, particularly in procedural domains, the time and resources available to train new cardiologists have dwindled. Simulation has become an increasingly important component of modern cardiology training, offering a safe, structured and reproducible environment in which clinical skills can be developed and refined.1 The term simulation encompasses a broad spectrum of educational approaches, ranging from focused task training to high-fidelity scenario-based learning.

Shingles vaccine protects against cardiovascular diseases Shingles vaccination reduced major adverse cardiac events and secondary cardiovascular outcomes for patients with atherosclerotic cardiovascular disease, according to new research.

Heart failure evidence update 2026 The interval since the 2021 European Society of Cardiology (ESC) Guidelines and 2022 American Heart Association/American College of Cardiology/Heart Failure Society of America (AHA/ACC/HFSA) Guidelines publications has witnessed an unprecedented volume of evidence that substantially expands the therapeutic landscape across the entire ejection fraction spectrum.

Guideline for the Evaluation and Management of Acute Pulmonary Embolism in Adults in 2026 The 2026 Guidelines for the Evaluation and Management of Acute Pulmonary Embolism in Adults, developed by the American Heart Association, the American College of Cardiology, the American College of Chest Physicians, the American College of Embolology et al.

Guideline on the Management of Dyslipidemia The new 2026 ACC/AHA/AACVPR et al. Guidelines for the Management of Dyslipidemia have been published. These guidelines address the assessment, treatment, and monitoring of individuals with dyslipidemia, including high blood cholesterol, elevated triglycerides, and elevated lipoprotein(a) [Lp(a)]. These new guidelines address primary, secondary, and primary prevention, provide guidance for care of adults and children, reinstate risk-based treatment targets for low-density lipoprotein (LDL) cholesterol, and replace the 2018 AHA/ACC/Multisociety Cholesterol Treatment Guidelines.

Quadpill Strategy Gains Ground in Hypertension Several new antihypertensive agents are reshaping the therapeutic strategies for patients with uncontrolled or resistant hypertension. Agents such as baxdrostat, the first selective aldosterone synthase inhibitor, and aprocitentan, a dual endothelin receptor A and B antagonist, are paving the way for new drug combinations and a more personalized approach to blood pressure control.

Heart Risks Rise, Care Lags: New Stats Expose Harsh Truths Researchers compiled a national data report on the burden, quality of care, and mortality trends for major cardiovascular risk factors and conditions in the US.

Updated recommendations for adults with congenital heart defects On December 18, updated guidelines for management of adults with congenital heart disease, developed by the American College of Cardiology (ACC) and the American Heart Association (AHA) in conjunction with several other societies, were published in Circulation and the Journal of the American College of Cardiology.

Can Interventional EP Go Outpatient? Is interventional electrophysiology poised for a paradigm shift? The American College of Cardiology and Heart Rhythm Society may think so. In a joint scientific statement, they offer guidance on performing certain procedures, such as cardiac ablation, in facilities that provide same-day surgical care without the need for hospital admission.