Engineered blood clots stop bleeding in secondsThe blood in the vascular system of the body supports vital functions, but when it leaves the body, it must quickly form a strong protective barrier — a clot that prevents death. However, because natural blood clots are known to form very slowly, heavy bleeding from accidents, battlefield injuries, and surgical complications leads to many potentially preventable deaths. In an article for the journal Nature, Jiang et al. They talked about the achievements of bioengineering that solve this problem by fundamentally changing the structure of blood clots.
Cardiovascular disease in Sickle cell: mechanisms, diagnostics and therapeutic advancesCardiovascular complications are increasingly recognized as a major cause of morbidity and early mortality in patients with sickle cell disease, yet they remain underdiagnosed and underestimated. In a new review, the authors summarize current knowledge on a wide range of cardiovascular manifestations, including myocardial dysfunction, pulmonary hypertension, cardiac iron overload, arrhythmia, myocardial infarction, stroke, and sudden death, with an emphasis on their unique pathophysiological mechanisms in Wolf-Hirschhorn syndrome.
Congenital heart disease in England: a national cohort study from fetal diagnosis to end of infancyPopulation-based studies of congenital heart defects (CHDs) often include only children who have undergone cardiac surgery, leading to an underestimation of the number of cases that do not require intervention. In a new study, the authors analyzed the outcomes of all identified cases of structural CHDs in England from prenatal to one year of age.
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